Lymphatic vascular specification and its modulation during embryonic development.
Identifieur interne : 002893 ( Main/Exploration ); précédent : 002892; suivant : 002894Lymphatic vascular specification and its modulation during embryonic development.
Auteurs : Cathy Pichol-Thievend [Australie] ; Benjamin M. Hogan [Australie] ; Mathias Francois [Australie]Source :
- Microvascular research [ 1095-9319 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Biologie du développement, Danio zébré, Facteurs de transcription (métabolisme), Humains, Lymphoedème (métabolisme), Mouvement cellulaire, Récepteurs Notch (métabolisme), Régulation de l'expression des gènes au cours du développement, Souris, Transcription génétique, Transduction du signal, Vaisseaux lymphatiques (physiologie).
- MESH :
- métabolisme : Facteurs de transcription, Lymphoedème, Récepteurs Notch.
- physiologie : Vaisseaux lymphatiques.
- Animaux, Biologie du développement, Danio zébré, Humains, Mouvement cellulaire, Régulation de l'expression des gènes au cours du développement, Souris, Transcription génétique, Transduction du signal.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Receptors, Notch, Transcription Factors.
- metabolism : Lymphedema.
- physiology : Lymphatic Vessels.
- Animals, Cell Movement, Developmental Biology, Gene Expression Regulation, Developmental, Humans, Mice, Signal Transduction, Transcription, Genetic, Zebrafish.
Abstract
Despite its essential roles in development and disease, the lymphatic vascular system has been less studied than the blood vascular network. In recent years, significant advances have been made in understanding the mechanisms that regulate lymphatic vessel formation, both during development and in pathological conditions. Remarkably, lymphatic endothelial cells are specified as a subpopulation of pre-existing venous endothelial cells. Here, we summarize the current knowledge of the transcription factor pathways responsible for lymphatic specification and we also focus on the factors that promote or restrict this event.
DOI: 10.1016/j.mvr.2014.07.011
PubMed: 25107456
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Despite its essential roles in development and disease, the lymphatic vascular system has been less studied than the blood vascular network. In recent years, significant advances have been made in understanding the mechanisms that regulate lymphatic vessel formation, both during development and in pathological conditions. Remarkably, lymphatic endothelial cells are specified as a subpopulation of pre-existing venous endothelial cells. Here, we summarize the current knowledge of the transcription factor pathways responsible for lymphatic specification and we also focus on the factors that promote or restrict this event.</div>
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<name sortKey="Francois, Mathias" sort="Francois, Mathias" uniqKey="Francois M" first="Mathias" last="Francois">Mathias Francois</name>
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